Neurotrophic Keratopathy Pre-survey

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Thank you for participating in this brief pre-survey. Your valuable feedback will be used to help us identify future areas for education. All data will be de-identified and reported in aggregate.

After you complete this survey, please visit www.catalystmeded.com/NK to view the content and earn your CME credit.

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How confident are you in your ability to diagnose neurotrophic keratopathy (NK)? *

Not confident

Very confident

How confident are you in your ability to appropriately use emerging treatments for NK? *

Not confident

Very confident

What stage of NK is characterized by friction from the eyelids resulting in fine or coarse punctate epithelial erosions of the cornea? *

Stage 1

Stage 2

Stage 3

Stage 4

Which of the following statements regarding early diagnosis of NK is LEAST ACCURATE? *

Non-healing epithelial damage starts in stage 2 NK.

In patients with herpetic keratitis, nerve loss cannot occur before corneal sensitivity is affected.

Patients may deny overt symptoms such as eye discomfort; therefore, it is important to ask the right questions about visual tasks that require sustained gazing such as reading or driving.

Extension lashes, contact lens wear, and chronic nasal allergy can affect the severity of NK.

Which of the following statements regarding the use of cenegermin for treatment of NK is CORRECT? *

It is a tear substitute that counteracts the effects of BAK.

It targets the nerve pathology associated with NK, not just the sequelae.

It eliminates the risk of potential for infection by allogeneic serum.

It is approved for use at this time only for stage 3 NK.

Which of the following statements regarding the safety and efficacy of available therapies for NK is CORRECT? *

The serum percentage of ASEDs ranges from 20% to 40%.

In randomized trials, 80% of those patients who received a full course of cenegermin treatment and achieved corneal epithelization remained healed at 48 weeks.

The response to human umbilical cord serum is 75% greater in those with moderate-to-severe NK.

Tear substitutes provide the essential components of human tears (ie, growth factors, fibronectin, and vitamins) while maintaining the biomechanical properties of tears.

Which of the following statements does NOT characterize appropriate management strategies for NK? *

The specific treatment goals will vary based on the stage of disease.

Some patients, especially those with early stage NK, may need to be made aware of the benefits of NK treatment, especially if they deny any discomfort from symptoms.

Combination treatments are not generally necessary.

Surgical interventions for NK are almost always reserved for patients with stage 2 or 3 NK.

A 66-year-old man with diabetes has a 2-year history of stage 1 NK. At his current visit, he reports experiencing reduced vision and discomfort in his right eye over the past few months that is associated with dry eye and difficulty reading. The patient tried artificial tears, topical steroids, and lubricating ointment previously. He has no history of ocular surgery or herpetic infection. Slit lamp examination reveals coarse punctate epithelial erosions and an epithelial defect with smooth, rolled edges which indicate stage 2 NK. Which of the following is the LEAST appropriate next step in managing his NK? *

Amniotic membrane transplantation

Restarting topical steroids and artificial tears

Initiating cenegermin

Placement of punctal plugs

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